pending update....


J.W. Yu, P. D. Jeffrey, J. Y. Ha, X. Yang, Y. Shi (2011) "Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region." Proc. Natl. Acad. Sci. USA, 108, 21004-21009 [PubMed]

G. Chen, L. R. Swem, D. L. Swem, D. L. Stauff, C. T. O'Loughlin, P. D. Jeffrey, B. L. Bassler, F. M. Hughson (2011) "A strategy for antagonizing quorum sensing." Mol Cell. 42, 199-209. [PubMed].

V. Stanevich, L. Jiang, K. A. Satyshur, Y. Li, P. D. Jeffrey, Z. Li, P. Menden, M. F. Semmelhack, Y. Xing (2011) "The structural basis for tight control of PP2A methylation and function by LCMT-1." Mol Cell., 41, 331-342. [PubMed]


Alas, nothing


Y. Ren, C. K. Yip, A. Tripathi, D. Huie, P. D. Jeffrey, T. Walz and F. M. Hughson (2009) "A Structure-based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1." Cell, 139, 1119-1129. [PubMed]

R. C. Kelly, M. E. Bolitho, D. A. Higgins, W. Lu, W.-L. Ng, P. D. Jeffrey, J. D. Rabinowitz, M. F. Semmelhack, F. M. Hughson and B. L. Bassler (2009) "The Vibrio cholerae Quorum-sending Autoinducer CAI-1: Analysis of the Biosynthetic Enzyme CqsA." Nature Chem. Biol., 5, 891-895. [PubMed]

J. Huhn, P. D. Jeffrey, K. Larsen, T. Rundberget, F. Rise, N. R. Cox, V. Arcus, Y. Shi and C. O. Miles (2009) "A Structural Basis for the Reduced Toxicity of Dinophysistoxin-2." Chem. Res. Toxicol., 22, 1782-1786. [PubMed]

D. A. Gell, L. Feng, S. Zhou, P. D. Jeffrey, K. Bendak, A. Gow, M. J. Weiss, Y. Shi, J. P. Mackay (2009) "A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin." J. Biol. Chem., 284, 29462-29469. [PubMed]

B. C. Richardson, R. D. Smith, D. Ungar, A. Nakamura, P. D. Jeffrey, V. V. Lupashin, F. M. Hughson (2009) "Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene." Proc. Natl. Acad. Sci. USA, 106, 13329-13334. [PubMed]

F. Zhang, M. Hu, G. Tian, P. Zhang, D. Finley, P. D. Jeffrey, Y. Shi (2009) "Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannashii." Mol. Cell, 34, 473-484. [PubMed]

A. Tripathi, Y. Ren, P. D. Jeffrey and F. M. Hughson (2009) "Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex." Nat. Struct. Mol. Biol., 16, 114-123. [PubMed]

J. W. Yu, P. D. Jeffrey and Y. Shi (2009) "Mechanism of Procaspase-8 Activation by c-FLIPL." Proc. Natl. Acad. Sci. U.S.A., 106, 8169-8174. [PubMed]

P. D. Jeffrey (2009) "Analysis of errors in the structure determination of MsbA." Acta Cryst., D65, 193-199. [PubMed]


A. Scrima, R. Konickova, B. K. Czyzewski, Y. Kawasaki, P. D. Jeffrey, R. Groisman, Y. Nakatani, S. Iwai, N. P. Pavletich, N. H. Thoma (2008) "Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex." Cell, 135, 1213-1223.

Y. Xu, Y. Chen, P. Zhang, P. D. Jeffrey, Y. Shi (2008) "Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation." Mol. Cell, 31, 873-885

Y. Xing, Z. Li, Y. Chen, J. B. Stock, P. D. Jeffrey, Y, Shi (2008) "Structural mechanism of demethylation and inactivation of protein phosphatase 2A." Cell, 133, 154-163.

Y. Xu, L. Feng, P. D. Jeffrey, Y. Shi, F. M. Morel (2008) "Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms." Nature, 452, 56-61.


L. Feng, H. Yan, Z. Wu, N. Yan, Z. Wang, P. D. Jeffrey, Y. Shi (2007) "Structure of a site-2 protease family intramembrane metalloprotease." Science, 318, 1608-1612.

G. Chen, P. D. Jeffrey, C. Fuqua, Y. Shi, L. Chen (2007) "Structural basis for antiactivation in bacterial quorum sensing." Proc. Natl. Acad. Sci. USA, 104, 16474-16479.

Y. Chen, Y. Xu, Q. Bao, Y. Xing, Z. Li, Z. Lin, J. B. Stock, P. D. Jeffrey and Y. Shi (2007) "Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40." Nat. Struct. Mol. Biol., 14, 527-534

A. Oberstein, P. D. Jeffrey and Y. Shi (2007) "Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein." J. Biol. Chem., 287, 13123-13132.


Z. Wu, N. Yang, L. Feng, A. Oberstein, H. Yan, R. P. Baker, L. Gu, P. D. Jeffrey, S. Urban and Y. Shi (2006) "Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry." Nature Struct. Mol. Biol., 13, 1084-1091.

Y. Xu, Y. Xing, Y. Chen, Y. Chao, Z. Lin, E. Fan, J.W. Yu, S. Strack, P.D. Jeffrey, Y. Shi (2006) "Structure of the protein phosphatase 2A holoenzyme". Cell 127, 1239-1251.

Z. Wu, N. Yan, L. Feng, A. Oberstein, H. Yan, R.P. Baker, L. Gu, P.D. Jeffrey, S. Urban, Y. Shi (2006) "Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry". Nat Struct Mol Biol. 13, 1084-1091.

Y. Xing, Y. Xu, Y. Chen, P.D. Jeffrey, Y. Chao, Z. Lin, Z. Li, S. Strack, J.B. Stock, Y. Shi (2006) "Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins." Cell 127, 341-353.

M.B. Neiditch MB, M.J. Federle, A.J. Pompeani, R.C. Kelly, D.L. Swem, P.D. Jeffrey, B.L. Bassler, F.M. Hughson (2006) "Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing." Cell 126, 1095-1108

Y. Chao, Y. Xing, Y. Chen, Y. Xu, Z. Lin, Z. Li, P.D. Jeffrey, J.B. Stock, Y. Shi Y (2006) "Structure and mechanism of the phosphotyrosyl phosphatase activator." Mol Cell 23, 535-546

M. Hu, L. Gu, M. Li, P. D. Jeffrey, W. Gu, Y. Shi (2006) "Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway". PLoS Biol 4, 228-239.

F. Y. Li, P. D. Jeffrey, J. W. Yu, Y. Shi (2006) "Crystal structure of a Viral FLIP: Insights into FLIP-mediated inhibition of death receptor signaling". J. Biol. Chem., 281, 2960-2968.


M. Hu, P. Li, L. Song, P. D. Jeffrey, T. A. Chenova, K. D. Wilkinson, R. E. Cohen, Y. Shi (2005) "Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14". EMBO J., 24, 3747-3756.

C. R. Antonescu, P. Besmer, T. Guo, K. Arkun, G. Hom, B. Koryotowski, M. A. Leversha, P. D. Jeffrey, D. Desantis, S. Singerd, M. F. Brennan, R. G. Maki, R. P. DeMatteo (2005) "Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation". Clin Cancer Res, 11, 4182-4190.

S. Li, K. R. Schmitz, P. D. Jeffrey, J. J. Wiltzius, P. Kussie, K. M. Ferguson (2005) "Structural basis for inhibition of the epidermal growth factor receptor by cetuximab". Cancer Cell, 7, 301-311.


Y. Huyen, P. D. Jeffrey, W. B. Derry, J. H. Rothman, N. P. Pavletich, E. S. Stavridi, T. D. Halazonetis (2004) "Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1". Structure, 12, 1237-1243.

J. P. Himanen, M. J. Chumley, M. Lackmann, C. Li, W. A. Barton, P. D. Jeffrey, C. Vearing, D. Geleick, D. A. Feldheim, A. W. Boyd, M. Henkemeyer, D. B. Nikolov (2004) "Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling". Nat. Neurosci., 7, 501-509.

E. S. Stavridi, K. G. Harris, Y. Huyen, J. Bothos, P. M. Verwoerd, S. E. Stayrook, N. P. Pavletich, P. D. Jeffrey, F. C. Luca (2004) "Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure 11, 1163-1170.


W. A. Barton, B. P. Liu, D. Tzvetkova, P. D. Jeffrey, A. E. Fournier, D. Sah, R. Cate, S. M. Strittmatter and D. B. Nikolov (2003) "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins". EMBO J., 22, 3291-3302.

G. Wu, G. Xu, B. A. Schulman, P. D. Jeffrey, J. W. Harper, N. P. Pavletich (2003) "Structure of a beta-TrCP1-Skp1-beta-catenin Complex: Destruction Motif Binding and Lysine Specificity of the SCF(beta-TrCP1) ubiquitin ligase". Mol. Cell, 11, 1445-1456.


R. A. Krykbaev, P. Tsantili, P. D. Jeffrey and M. N. Margolies (2002) "Modifying Specificity of Antidigoxin Antibodies using Insertional Mutagenesis". Protein Sci., 11, 2899-2908.

H. Yang, P. D. Jeffrey, J. Miller, E. Kinnucan, Y. Sun, N. H. Thoma, N. Zheng, P. L. Chen, W. H. Lee and N. P. Pavletich (2002) "BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure". Science, 297, 1837-1848.

E. S. Stavridi, Y. Huyen, I. R. Loreto, D. M. Scolnick, T. D. Halazonetis, N. P. Pavletich and P. D. Jeffrey (2002) "Crystal Structure of the FHA Domain of the Chfr Mitotic Checkpoint Protein and its Complex with Tungstate". Structure, 10, 891-899.

W. S. Joo, P. D. Jeffrey, S. B. Cantor, M. S. Finnin, D. M. Livingston and N. P. Pavletich (2002) "Structure of the 53BP1 BRCT Region bound to p53 and its Comparison to the Brca1 BRCT structure". Genes Dev., 16, 583-593.

N. Zheng, B. A. Schulman, L. Song, J. J. Miller, P. D. Jeffrey, P. Wang, C. Chu, D. M. Koepp, S. J. Elledge, M. Pagano, R. C. Conaway, J. W Harper and N. P. Pavletich (2002) "Structure of the Cul1-Rbx1-Skp1-Fbox SCF Ubiquitin Ligase Complex". Nature, 416, 703-709.

M. K. Short, R. A. Krykbaev, P. D. Jeffrey and M. N. Margolies (2002) "Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26-10 Permit High Affinity Wild-type Binding". J. Biol. Chem. 277, 16365-16370.


M. K. Short, P. D. Jeffrey, A. Demirjian and M. N. Margolies (2001) "A Single H:CDR3 Residue in the Anti-digoxin Antibody 26-10 Modulates Specificity for C16-substituted Digoxin Analogs." Protein Eng. 14, 287-296.

W. A. Barton, J. Lesniak, J. B. Biggins, P. D. Jeffrey, J. Jiang, K. R. Rajashankar, J. S. Thorson and D. B. Nikolov (2001) "Structure, Mechanism and Engineering of a Nucleotidylyltransferase as a first step toward Glycorandomization". Nat. Struct. Biol. 8, 545-551.

R. A. Krykbaev, W. R. Liu, P. D. Jeffrey and M.N. Margolies (2001) "Phage Display-selected Sequences of the Heavy-chain CDR3 Loop of the Anti-digoxin Antibody 26-10 Define a High-affinity Binding Site for Position 16-substituted Analogs of Digoxin". J. Biol. Chem. 276, 8149-8158.


P. D. Jeffrey, L. Tong and N. P. Pavletich (2000) "Structure of the Ternary Complex of Cdk6 with p18(INK4c) and a Viral CyclinD Homolog". Genes Dev. 14, 3115-3125.

B. A. Schulman, A. C. Carrano, P. D. Jeffrey, Z. Bowen, E. R. Kinnucan, M. S. Finnin, S. J. Elledge, J. W. Harper, M. Pagano and N. P. Pavletich (2000) "Insights into SCF ubiquitin ligases from the Structure of the Skp1-Skp2 Complex". Nature 408, 381-386.

N. Zheng, P. Wang, P. D. Jeffrey and N. P. Pavletich (2000) "Structure of a c-Cbl-UbcH7 Complex: RING Domain Function in Ubiquitin-protein Ligases". Cell 102, 533-539.


M. C. Bewley, P. D. Jeffrey, M. L. Patchett, Z. F. Kanyo and E. N. Baker (1999) "Crystal Structures of Bacillus caldevelox Arginase in Complex with Substrate and Inhibitors Reveal New Insights into Activation, Inhibition and Catalysis in the Arginase Superfamily". Structure 7, 435-448.

A. A. Russo, L. Tong, J.O. Lee, P. D. Jeffrey and N. P. Pavletich (1998) "Structural Basis for Inhibition of the Cyclin-dependent Kinase CDK6 by the Tumour Suppressor p16INK4a". Nature 395, 237-243.


P. D. Jeffrey, M. C. Bewley, R. T. McGillivray, A. B. Mason, R. C. Woodworth and E. N. Baker (1998) "Ligand-induced Conformational Change in Transferrins: Crystal Structure of the Open Form of the N-terminal Half-molecule of Human Transferrin". Biochemistry 37, 13978-13986.



A. A. Russo, P. D. Jeffrey, A. Patten, J. Massague and N. P. Pavletich (1996) "Crystal Structure of the p27Kip1 Cyclin-Dependent Kinase Inhibitor Bound to the CyclinA-CDK2 Complex". Nature 382, 325-331.

A. A. Russo, P. D. Jeffrey and N. P. Pavletich (1996). "Structural Basis of Cyclin-Dependent Kinase Activation by Phosphorylation". Nature Struct. Biol. 3, 696-700.

S. Sheriff, P. D. Jeffrey and J. Bajorath (1996) "Comparison of CH1 Domains in Different Classes of Murine Antibodies". J. Mol. Biol. 263, 385-389.

S. Sheriff, C. Y. Chang, P. D. Jeffrey and J. Bajorath (1996). "X-ray Structure of the Uncomplexed Anti-Tumor Antibody BR96 and Comparison with its Antigen-Bound Form". J. Mol. Biol. 259, 938-946.

S. Chacko, E. W. Silverton, S. J. Smith-Gill, D. R. Davies, K. A. Shick, K. A. Xavier, R. C. Willson, P. D. Jeffrey. C. Y. Chang, L. C. Sieker and S. Sheriff (1996). "Refined Structures of Bob-White Quail Lysozyme Uncomplexed and Complexed with the HyHEL-5 Fab Fragment". Proteins 26, 55-65.


M. K. Short, P. D. Jeffrey, R. F. Kwong and M. N. Margolies (1995). "Contribution of Antibody Heavy Chain CDR1 to Digoxin Binding Analyzed by Random Mutagenesis of Phage-Displayed Fab 26-10". J. Biol. Chem. 270, 28541-28550.

P. D. Jeffrey, A. A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massague and N. P. Pavletich (1995). "Mechanism of CDK Activation Revealed by the Structure of a CyclinA-CDK2 Complex". Nature 376, 313-320.

P. D. Jeffrey, J. Bajorath, C. Y. Chang, D. Yelton, I. Hellstrom, K. E. Hellstrom and S. Sheriff (1995). "The X-ray Structure of an Anti-Tumour Antibody in Complex with Antigen". Nature Struct. Biol. 2, 466-471.

P. D. Jeffrey, S. Gorina and N. P. Pavletich (1995). "Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms". Science 267, 1498-1502.

P. D. Jeffrey, J. F. Schildbach, C. Y. Chang, P. Kussie, M. N. Margolies and S. Sheriff (1995). "Structure and Specificity of the Anti-Digoxin Antibody 40-50". J. Mol. Biol. 248, 344-360.

J. F. Schildbach, M. E. Milla, P. D. Jeffrey, B. E. Raumann and R. T. Sauer (1995). "Crystal Structure, Folding, and Operator Binding of the Hyperstable Arc Repressor Mutant PL8". Biochemistry 34, 1405-1412.


Y. Cho, S. Gorina, P. D. Jeffrey and N. P. Pavletich (1994). "Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations". Science 265, 346-355.

C. Y. Chang, H. Shih, P. D. Jeffrey, M. N. Margolies and S. Sheriff (1994). "Crystallization and Preliminary X-ray Analysis of Anti-Digoxin Antibodies". Acta Cryst. D50, 915-917.

J. F. Schildbach, S.-Y. Shaw, R. E. Bruccoleri, E. Haber, L. A. Herzenberg, G. C. Jager, P. D. Jeffrey, D. J. Panka, R. I. Near, J. Novotny, S. Sheriff and M. N. Margolies (1994). "Contribution of a Single Heavy Chain Residue to Specificity of an Anti-Digoxin Monoclonal Antibody". Protein Science 3, 737-749.

C. Y. Chang, P. D. Jeffrey, J. Bajorath, I. Hellstrom, K. E. Hellstrom and S. Sheriff (1994). "Crystallization and Preliminary X-ray Analysis of the Monoclonal Anti-tumor Antibody BR96 and its Complex with the Le/y Determinant". J. Mol. Biol. 235, 372-376.


P. D. Jeffrey, R. K. Strong, L. C. Sieker, C. Y. Chang, R. L Campbell, G. A. Petsko, E. Haber, M. N. Margolies and S. Sheriff (1993). "Structure of the Anti-Digoxin Fab 26-10 as a Complex with Digoxin at 2.5 Angstrom Resolution". Proc. Natl. Acad. Sci. U.S.A. 90, 10310-10311.

J. F. Schildbach, R. I. Near, R. E. Bruccoleri, E. Haber, P. D. Jeffrey, J. Novotny, S. Sheriff and M. N. Margolies (1993). "Modulation of Antibody Affinity by a Non-Contact Residue". Protein Science 2, 206-214.

J. F. Schildbach, R. I. Near, R. E. Bruccoleri, E. Haber, P. D. Jeffrey, S.-C. Ng, J. Novotny, S. Sheriff and M. N. Margolies. (1993). "Heavy chain position 50 is a determinant of affinity and specificity for the anti-digoxin antibody 26-10". J. Biol.Chem. 268, 21739-21747.

V. Goldfarb, M. Wittekind, P. D. Jeffrey, L. Mueller and K. L. Constantine. (1993). "Reconstitution and Characterization of an Antibody Fv Fragment 15N-Labelled in the VL Domain Only". J. Mol. Biol. 232, 15-22


K. L. Constantine, M. S. Friedrichs, V. Goldfarb, P. D. Jeffrey, S. Sheriff and L. Mueller. (1992). "Characterization of the Backbone Dynamics of an Anti-Digoxin Antibody VL Domain by Inverse Detected 1H-15N NMR: Comparisons with X-ray Data for the Fab". Proteins: Struct. Funct. Genet. 15, 290-311.


R. E. Griest, P. D. Jeffrey, G. L. Taylor and A. R. Rees. (1991). "Crystallization and Characterization of the Antigen-Binding Fragments of Anti-Peptide Monoclonal Antibodies and their Complexes with Peptide". J. Mol. Biol. 223, 381-382.